What do you know about Lorazepam?


1 has a sedative effect
2 is used to alleviate anxiety
3 may cause ataxia in AB

A 1, 2, 3
B 1, 2 only
C 2, 3 only
D 1 only
E 3 onlyvv


  1. A is the answer and the winners are Eze and 8th avenue
    Details Below:
    Lorazepam is a short-acting benzodiazepine that has anti-anxiety and hypnotic
    properties. Use of benzodiazepines in older people is associated with alter-
    ations in the pharmacokinetic parameters of the drug that lead to clinical
    consequences such as drowsiness, confusion and ataxia (a condition charac-
    terised by an inability to coordinate movement). The probability of occurrence
    of these side-effects is higher with drugs that have a long halflife. The use of
    lorazepam in AB raises concern as it appears that there is no clear rationale
    for its use. More data is required as to reasons for its use and duration of
    therapy. It may have been started recently when the patient was becoming
    agitated because of the insidious deterioration of his wellbeing. Owing to the
    onset of benzodiazepine dependence, lorazepam should not be stopped
    abruptly if the patient has been taking the drug for a few weeks. Abrupt with-
    drawal is associated with the benzodiazepine withdrawal syndrome charac-
    terised by anxiety, depression, impaired concentration, insomnia, headache
    and loss of appetite.


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