pharmacy
Plasma concentration of phenytoin is increased by:
1 ❏ amoxicillin
2 ❏ doxycycline
3 ❏ clarithromycin
ONE or MORE of the responses above is (are) correct. Decide which of the responses is (are) correct. Then choose:
A ❏ if 1, 2 and 3 are correct
B ❏ if 1 and 2 only are correct
C ❏ if 2 and 3 only are correct
D ❏ if 1 only is correct
E ❏ if 3 only is correct
The answer is E, winners are O’can and Odogwu. Details below:
Metabolism of phenytoin (anti-epileptic drug) is inhibited by clarithromycin
(macrolide antibacterial agent) resulting in an increased plasma concentration
of phenytoin. Phenytoin accelerates metabolism of doxycycline (tetracycline
antibacterial drug) resulting in a reduced plasma concentration of doxycycline.
E
D
A
A
E
B
B
D
D
E