Which enzyme is primarily responsible for the metabolism of codeine…

PANS QUIZ

1. Which enzyme is primarily responsible for the metabolism of codeine into morphine, its more potent opioid metabolite?
A. CYP1A2
B. CYP2D6
C. CYP3A4
D. CYP2C19

2. A drug with a narrow therapeutic index generally requires closer monitoring because a small difference between its therapeutic and toxic concentrations can have significant clinical consequences.
True
False

3. Which of the following are recognised mechanisms by which bacteria develop resistance to antibiotics? Select all that apply.
A. Alteration of the antibiotic’s target site
B. Increased permeability of the bacterial cell membrane
C. Active efflux of antibiotics from bacterial cells
D. Enzymatic destruction or modification of the antibiotic

4. The first-pass effect can reduce the oral bioavailability of a drug before it reaches systemic circulation.
A.True
B.False