Which Of The Following Best Explains Why Aminoglycosides Can Cause Ototoxicity?
A. They Irreversibly Inhibit Protein Synthesis In Cochlear Hair Cells By Binding To 50S Ribosomal Subunits.
B. They Accumulate In The Perilymph And Endolymph Of The Inner Ear, Generating Reactive Oxygen Species That Damage Sensory Hair Cells.
C. They Competitively Block NMDA Receptors In The Auditory Cortex, Leading To Hearing Loss.
D. They Inhibit Calcium Channels In The Middle Ear, Reducing Neurotransmitter Release And Causing Hearing Deficits.
It’s primarily caused by the accumulation of the drug in the inner ear leading to hair cell damage and apoptosis in the cochlea
B
Ototoxicity came to the forefront of clinical attention with the discovery of streptomycin in 1944. Streptomycin was used successfully in the treatment of tuberculosis; however, a substantial number of treated patients were found to develop irreversible cochlear and vestibular dysfunction
B
B
Answer is B
B
B
B
B