PANS QUIZ
Which of the following best explains why abrupt cessation of prolonged benzodiazepine misuse can precipitate life-threatening seizures?
A. Sudden accumulation of benzodiazepine metabolites in the brain.
B. Rebound central nervous system hyperexcitability following neuroadaptation to enhanced GABA-A activity.
C. Irreversible blockade of dopamine D2 receptors in the basal ganglia.
D. Acute depletion of acetylcholine at neuromuscular junctions.
A person who chronically misuses opioids is revived with naloxone following an overdose. Why can respiratory depression return after initial recovery?
A. Naloxone stimulates opioid receptors after its initial antagonistic effect.
B. Naloxone increases opioid absorption from the gastrointestinal tract.
C. The opioid may outlast naloxone, allowing respiratory depression to recur as naloxone wears off.
D. Naloxone permanently depletes endogenous opioid peptides.
B
C
B
C
B
C
1. B
2. C
B
C
B
C