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If a drug’s t½ is 8 hr, how long will it take to reach >95% steady state with continuous dosing?

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PANS QUIZ

If a drug’s t½ is 8 hr, how long will it take to reach >95% steady state with continuous dosing?
A. 16 hr
B. 24 hr
C. 32 hr
D. 40 hr

A drug’s oral F = 0.8, Vd = 20 L, and desired C₀ = 5 mg/L. What loading dose (oral) is needed?
A. 100 mg
B. 125 mg
C. 150 mg
D. 200 mg

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