Isosorbide mononitrate has?


1    has a longer half-life than the dinitrate salt

2    has poor bioavailability after oral administration

3    is used in hypertension


A    1, 2, 3

B    1, 2 only

C    2, 3 only

D    1 only

E    3 only


  1. D is the answer and there is no winner to this question.
    Details Below:
    Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Advan-
    tages over isosorbide dinitrate include a higher bioavailability after oral
    administration as it does not undergo first-pass hepatic metabolism and a
    longer halflife. Isosorbide mononitrate is used in the prophylaxis of angina
    and in congestive heart failure.

  2. A is the answer and the winners are Eze and Clement.
    Details Below:
    There is great inter-patient variation in the course of the disease. Onset is
    insidious and the disease usually presents initially with non-specific symptoms
    such as fatigue, malaise, diffuse musculoskeletal pain and stiffness. Charac-
    teristically, at onset the patient presents with symmetrical small-joint polyarthri-
    tis in the hands, wrists and feet. Diagnostic criteria for rheumatoid arthritis
    include presence of morning stiffness, presence of arthritis in three or more
    joints, symmetrical involvement, rheumatoid nodules, serum rheumatoid factor
    and radiographic changes.


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