Researchers Get Close to Discovering Why Eczema Happens

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A new study from researchers at Binghamton State University of New York may help to peel the layers of unhealthy skin and get closer to a cure.

Over 35 million people suffer from eczema, a chronic skin condition also known as atopic dermatitis. Worldwide, two to five per cent of adults and about 15 per cent of children suffer from symptoms such as dry, inflamed and very itchy skin with open sores.

According to research, eczema is an inflammation of the skin characterized by reddening, swelling, bumps and crusting, followed by thickening and scaling. It is also referred to as dermatitis. It refers to a chronic inflammatory skin condition, characterized by dry skin, with patches that are red and intensely itchy

Although there are myriads of treatments for eczema, such as medical creams and natural remedies, the exact causes of the condition remain elusive.

Eczema affects millions of people, and most of them are infants and children. Ten per cent to 20 per cent of all infants have eczema, according to the National Institutes of Health. However, nearly half outgrow the condition.  It usually appears in children between 6 months and 5 years old, according to the National Eczema Association. Rashes usually begin on the face, scalp, hands and feet. The problem can last throughout childhood and into adulthood.

In a new paper, the team—Associate Professor Guy German and Ph.D. student Zachary W. Lipsky from the Thomas J. Watson School of Engineering and Applied Science’s Department of Biomedical Engineering, and Associate Professor Claudia N.H. Marques of the Harpur College of Arts and Sciences’ Department of Biological Sciences—connects two aspects of eczema research that are rarely studied together.

One result of atopic dermatitis is a decreased level of skin oils known as lipids, particularly one group called ceramides. Lipids on the surface of the skin function to regulate hydration and also help defend the skin from foreign invaders either indirectly through immune signaling or directly through their inherent antimicrobial activity.

Another result of eczema is an increase in staph bacteria in the skin, which can cause irritation and infection.

German said that genetics can play a part in whether someone has eczema, but people in certain occupations have also been shown to be more likely to get the skin condition, such as healthcare professionals, metalworkers, hairdressers and food processing workers. The connection? An increased amount of handwashing or regular contact with detergents for your job.

“What happens if, either through a mutation or through occupational risks, there’s a decreased presence of lipids on the skin?” he asked. “The essence of this study is that in normal, healthy conditions, bacteria do not penetrate the skin barrier. In atopic dermatitis conditions or lipid levels consistent with AD, it does—and it consistently takes nine days.”

Because the staph bacteria are immobile, they need to multiply in number to grow through the protective outer skin layer known as the stratum corneum. The Watson researchers believe the bacteria don’t grow around the skin cells but actually through them. With lipid depletion—either through genetics or occupational risks—the skin appears to become more vulnerable to bacterial invasion and infection of underlying skin tissue.

“When we usually think about the oils in our skin, we think about water retention and moisturizing—things like that,” Lipsky said. “Now we’re looking at how these lipids are important for protection against these microorganisms that can come in and cause diseases.”

While this study has not unlocked all the secrets of atopic dermatitis, showing that the bacteria could be the cause rather than the result of the disease is a major step forward. Further research is required, and that’s where the Watson team will investigate next.

“Now that we know that bacteria can permeate through lipid depleted skin, how does it affect the skin mechanically?” Lipsky asked. “Does it make the skin weaker and more likely to crack? Can we figure out how bacteria are moving through different skin layers?”

German added: “In scientific research, you get one answer and three additional questions pop up, so we’re never stuck for things to do.