Which of this statement is correct about Colchicine?


1    should be used when there is a contraindication to NSAIDs

2    is more toxic than NSAIDs

3    occurrence of diarrhea and vomiting are used as an index to review therapy

 A    1, 2, 3

B    1, 2 only

C    2, 3 only

D    1 only

E    3 only


  1. A is the answer and the winners are Eze and Clement.
    Details Below:
    Usually non-steroidal anti-inflammatory drugs are used as first-line treatment in
    the management of acute attacks of gout. They counteract the pain and reduce
    the inflammation. JZ suffers from heart failure and colchicine is preferred to
    avoid the fluid retention that may occur with NSAIDs. Also, NSAIDs may
    interact with the medications that JZ is taking, namely the diuretics and antihypertensive agents, causing a decrease in the hypotensive effect. Although
    this interaction is usually not of clinical significance, it is worth considering
    other therapeutic options. The disadvantage of colchicine is that it is commonly
    associated with side-effects, particularly signs of gastrointestinal toxicity manifested as diarrhoea and vomiting. Occurrence of these side-effects indicates
    that the dose should be reviewed. Colchicine is associated with cumulative
    toxicity and diarrhoea, nausea, vomiting and abdominal pain are the first
    signs of toxicity. The dose should be stopped or reduced depending on the
    patient’s symptoms


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