1 should be used when there is a contraindication to NSAIDs
2 is more toxic than NSAIDs
3 occurrence of diarrhea and vomiting are used as an index to review therapy
A 1, 2, 3
B 1, 2 only
C 2, 3 only
D 1 only
E 3 only
Which of this statement is correct about Colchicine?
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A is the answer and the winners are Eze and Clement.
Details Below:
Usually non-steroidal anti-inflammatory drugs are used as first-line treatment in
the management of acute attacks of gout. They counteract the pain and reduce
the inflammation. JZ suffers from heart failure and colchicine is preferred to
avoid the fluid retention that may occur with NSAIDs. Also, NSAIDs may
interact with the medications that JZ is taking, namely the diuretics and antihypertensive agents, causing a decrease in the hypotensive effect. Although
this interaction is usually not of clinical significance, it is worth considering
other therapeutic options. The disadvantage of colchicine is that it is commonly
associated with side-effects, particularly signs of gastrointestinal toxicity manifested as diarrhoea and vomiting. Occurrence of these side-effects indicates
that the dose should be reviewed. Colchicine is associated with cumulative
toxicity and diarrhoea, nausea, vomiting and abdominal pain are the first
signs of toxicity. The dose should be stopped or reduced depending on the
patient’s symptoms
B
B
A
A
A