Test Your Knowledge On Drug Antagonism


A drug that is an antagonist is:
A valsartan
B lisinopril
C morphine
D simvastatin
E insulin


  1. A is the answer, Collins and O’can are winners.
    Valsartan is an angiotensin-II receptor antagonist that blocks the actions of
    angiotensin resulting in lowering of blood pressure. Lisinopril is an angiotensin￾converting enzyme (ACE) inhibitor that inhibits the conversion of angiotensin
    I to angiotensin II. Angiotensin I is an inactive precursor of angiotensin II that
    has a variety of activities including vasoconstriction. Morphine is an opioid
    analgesic that acts as an agonist at endorphin receptors. Simvastatin is a statin
    that acts by competitively inhibiting the enzyme HMG-CoA (3-hydroxy-
    3-methyl-glutaryl-CoA) reductase that controls the synthesis of cholesterol in the
    liver. Insulin is a peptide that is normally produced by the pancreas.


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