Potentially hazardous interactions could occur between:
1 ❏ ergotamine and zolmitriptan
2 ❏ warfarin and gliclazide
3 ❏ combined oral contraceptives and clindamycin
ONE or MORE of the responses above is (are) correct. Decide which of the responses is
(are) correct. Then choose:
A ❏ if 1, 2 and 3 are correct
B ❏ if 1 and 2 only are correct
C ❏ if 2 and 3 only are correct
D ❏ if 1 only is correct
E ❏ if 3 only is correct
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The answer is B.And Solace is the winner.
See explaination below:
Both ergotamine and zolmitriptan are indicated for migraine attacks. When
ergotamine and zolmitriptan are administered concurrently there is an
increased risk of vasospasm. Use of ergotamine should be avoided for 6 h
after administration of zolmitriptan, and use of zolmitriptan should be avoided
for 24 h after administration of ergotamine. This reaction could be potentially
hazardous. When warfarin is administered to a patient receiving a sulphonylurea such as gliclazide, this could enhance the hypoglycaemic effect and may
also result in changes in the anticoagulant effect. There is no evidence of a
potentially hazardous interaction when clindamycin is administered to patients
receiving combined oral contraceptives.
C
B
B
B