pharmacy
The following statements concerning mechanism of calcium channel blockers’ action are true, EXCEPT:
a) Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in vascular smooth muscle target tissues
b) Calcium channel blockers bind to L-type calcium channel sites
c) Calcium channel blockers useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)
d) Calcium channel blockers decrease transmembrane calcium current associated in smooth muscle with long-lasting relaxation and in a cardiac muscle with a reduction in contractility
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A