What do you understand by the mechanism of valproate action?


The mechanism of valproate action is:

a) Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABAaminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation)

b) Inhibition of voltage sensitive Na+ channels

c) Inhibition of low threshold (T-type) Ca2+ channels

d) All of the above


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