Which antiarrhythmic drug blocks potassium channels, sodium channels, and has beta-blocking and calcium channel blocking effects?
A. Amiodarone
B. Sotalol
C. Propafenone
D. Dronedarone
A 65-year-old man on digoxin for heart failure starts clarithromycin. Two weeks later, he develops confusion and arrhythmia. What is the most likely mechanism?
A. Clarithromycin decreases digoxin absorption
B. Clarithromycin inhibits P-glycoprotein, increasing digoxin levels
C. Clarithromycin induces CYP3A4, increasing digoxin clearance
D. Clarithromycin chelates digoxin in the GI tract
A
B
A
B
A
B
A
B
A
B
A B
A
B
Ab
A
B
A
B
A
B
A,B