Which antiviral requires pharmacokinetic boosting with ritonavir due to extensive CYP3A4 metabolism?

Which antiviral requires pharmacokinetic boosting with ritonavir due to extensive CYP3A4 metabolism?
A. Lamivudine
B. Lopinavir
C. Zidovudine
D. Abacavir

A poorly soluble drug’s oral bioavailability is increased by reducing particle size to the nanometer scale. This primarily enhances:
A. Drug permeability
B. Drug stability
C. Dissolution rate
D. Hepatic metabolism