Which of the Following Statements about First-Pass Metabolism are correct?

Which of the following statements about first-pass metabolism are correct?
1 ❏ It refers to the metabolism of a drug before it reaches systemic circulation
2 ❏ Drugs with high first-pass metabolism may require alternative routes of administration, such as sublingual or intravenous
3 ❏ First-pass metabolism primarily occurs in the kidneys before the drug enters the liver

Instructions:
Choose:
A ❏ if 1, 2, and 3 are correct
B ❏ if 1 and 2 only are correct
C ❏ if 2 and 3 only are correct
D ❏ if 1 only is correct
E ❏ if 3 only is correct