Which of the following statements is not correct for local anesthetics?

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Which of the following statements is not correct for local anesthetics?

a) In a tissue they exist either as an uncharged base or as a cation

b) A charged cationic form penetrates biologic membranes more readily than an uncharged form

c) Local anesthetics are much less effective in inflamed tissues

d) Low ph in inflamed tissues decreases the dissociation of nonionized molecules

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