A poorly soluble drug’s oral bioavailability is increased by reducing particle size to the nanometer scale.

A poorly soluble drug’s oral bioavailability is increased by reducing particle size to the nanometer scale. This primarily enhances:
A. Drug permeability
B. Drug stability
C. Dissolution rate
D. Hepatic metabolism

According to ICH stability guidelines (Q1A), what is the minimum duration of long-term stability testing for a drug intended for Zone IVB (hot and very humid) before marketing approval?
A. 3 months
B. 6 months
C. 12 months
D. 12 months long-term + 6 months accelerated