Leflunomide:
A ❏ its therapeutic effect starts after 4–6 weeks
B ❏ is given as an initial dose of 7.5 mg
C ❏ is administered once a week
D ❏ is available only for parenteral administration
E ❏ no washout procedures are required when changing to
another product
The answer is A and all respondents got it, but the first to answer correctly is Hendrix.
Leflunomide is a disease-modifying antirheumatic drug that exerts its
therapeutic effect 4–6 weeks after initiation of treatment. It is started at 100 mg
once daily for 3 days and then a maintenance dose of 10–20 mg once daily
is recommended. It is available as tablets at 10 mg, 20 mg or 100 mg
strengths. The active metabolite of leflunomide persists for a long period, so
washout procedures are required in case of serious adverse effects or before
changing to another disease-modifying antirheumatic drug.
A
A
A