Which antiviral requires pharmacokinetic boosting with ritonavir due to extensive CYP3A4 metabolism?A. Lamivudine
B. Lopinavir
C. Zidovudine
D. Abacavir
A liquid formulation of an antibiotic shows a shelf life of 6 months at 25 °C. If the degradation follows first-order kinetics with an activation energy of 60 kJ/mol, how will its shelf life change if stored at 35 °C? (Use Arrhenius equation approximation: shelf life halves for every 10 °C rise when Ea ≈ 50–70 kJ/mol)
A. ~3 months
B. ~4 months
C. ~6 months
D. ~12 months
C
D
B
A
B
A
B
A
B
B
A
1 B
2 A
B
A
B
A