Which of the following statements about estrogens are True:

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Which of the following statements about estrogens are True:

a) Estradiol binds strongly to an α2-globulin and albumin with lower affinity

b) Estradiol is converted by liver and other tissues to estron and estriol and their 2-hydroxylated derivatives and  conjugated metabolites and excreted in the bile .

c) Estrone and estriol have lower affinity for the estrogen receptors than estradiol

d) All of the above

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