Which of the following statements about estrogens are True:
a) Estradiol binds strongly to an α2-globulin and albumin with lower affinity
b) Estradiol is converted by liver and other tissues to estron and estriol and their 2-hydroxylated derivatives and conjugated metabolites and excreted in the bile .
c) Estrone and estriol have lower affinity for the estrogen receptors than estradiol
d) All of the above